Oral administration of tenofovir fasting bioavailability of approximately 25% and 40% (during eating); improved by taking with meals, especially with high fat content. Clinically significant impact on the effectiveness of tenofovir meal does not have. After receiving a single oral dose of 300 mg on an empty stomach, the maximum serum concentration is achieved after 1 ± 0,4 h. The pharmacokinetics of tenofovir has a dose-dependent manner. The proviron buy; After a single oral admission of tenofovir, the T1 / 2 of tenofovir -. About 17 hours after multiple oral receiving a dose of 300 mg 1 time per day (in terms of proviron side effects reception is not fasting), 32 + 10% of the dose is determined in the urine over 24 hours. Tenofovir is excreted by the kidneys by glomerular filtration and active tubular secretion.
Treatment of HIV-1 infection as part of combination antiretroviral therapy in adults.
Tenofovir is contraindicated in patients with hypersensitivity to any component of the formulation.
Renal impairment with proviron buy, including patients on hemodialysis. When creatinine clearance less than 30 ml / min use of the drug should be avoided; in case other. Treatment N should carefully monitor renal function and to adjust the interval between administration of the drug.
Pregnancy and lactation
When deciding to use the drug during pregnancy is necessary to correlate the expected therapeutic effect for the mother and the possible risk of the drug to the fetus. In connection with the bone identify changes in patients receiving the drug, and the limited use of the experience is recommended to use the drug with caution during pregnancy. Women of childbearing age during treatment should use reliable methods of contraception.
Nursing mothers: HIV-infected women should be instructed to exclude breastfeeding.
Dosage and administration
Inside, regardless of meals. The recommended dose for the treatment of HIV-1 infection: 300 mg 1 time per day. The recommended dosing regimen Tenofovir in renal insufficiency: Creatinine clearance 30-49 ml / min: 300 mg every 48 h creatinine clearance 10-29 ml / min. 300 mg every 72-96 hours Hemodialysis: 300 mg every 7 days following completion of the session dialysis. Recommendations proviron buy for dosing regimen in patients with a creatinine clearance less than 10 mL / min (without dialysis) are absent.
The following are adverse reactions with suspected (possible) connection with a drug listed on a system-organ classes in descending order of severity, with the following frequency: very common (> 1/10) and common (> 1/100, <1 / 10), rare (> 1/10000, <1/1000), very rare (<1/10000), including isolated cases.
Violation of metabolism and nutrition: very often – hypophosphatemia. From the nervous system : very often – dizziness.
From the gastrointestinal tract: often – diarrhea, vomiting, nausea; . often – bloating combined retroviral therapy was associated with metabolic disorders such as hypertriglyceridemia, hypercholesterolemia, insulin resistance, hyperglycemia and hyperlactatemia; redistribution of subcutaneous fat proviron buy (lipodystrophy). Cases of osteonecrosis, especially in patients with risk factors or long-term combined antiviral therapy. The frequency is not known.